Bright lights: Mystery of glowing antibody solved


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Bright lights: Mystery of glowing antibody solved by Scripps research scientists

Now, a group of Scripps Research scientists have shown that EP2-19G2, one of a panel of fluorescent monoclonal antibodies that were first reported in 2000, produces its distinctive bright blue glow through a rare and highly complex recombination of electrical charge.
This charge recombination involves an electron hole—the gap left by the electron as it is transferred from one molecule to the other.
The new study was published in the February 29, 2008 edition (Volume 319, Number 5867) of the journal Science.

“Our study describes in detail the rare and rather surprising mechanism that creates this exceptionally bright and long-lasting fluorescent antibody,” said Richard Lerner, president of The Scripps Research Institute, Lita Annenberg Hazen Professor of Immunochemistry, and member of the Skaggs Institute for Chemical Biology at Scripps Research. “These findings could have wide application in the development of novel and more broadly applicable biosensors.”

why believe me call the scientist; it's new material.....

Public release date: 28-Feb-2008
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Contact: Mika Benedyk
Scripps Research Institute